• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    The present invention relates to a nicotine inhaler and a method for producing the same. Such a device enables a user to inhale nicotine vapors and it is primarily intended to be used as an aid to smoking cessation.
    公开号:SE0900880A1
    申请号:SE0900880
    申请日:2009-06-29
    公开日:2010-12-30
    发明作者:John Wollin
    申请人:John Wollin；
    IPC主号:
    专利说明:

    Background of the Invention Several attempts have been made over the years to create useful aids for smokers to manage their nicotine abuse. The most successful product is nicotine chewing gum. Another product for this purpose is a smoke-free cigarette which, however, could not fully meet FDA requirements. Oral intake of nicotine vapors was considered a very effective way to help with smoking cessation. A lot of development has been put in to create a good and safe product in this regard. Such products have been described in detail in e.g. U.S. Patents 4,736,755, 4,917,120, 5,167,242, 5,400,808, 5,512,366 and 6,098,632 whose contents are included in this patent application. A product based on one or more of these patents has been developed and marketed under the Nicorette® Inhaler® brand. In this product, the nicotine is encapsulated in a porous polyolefin plug mounted in a cylinder (tube) that is injection molded into modified acrylonitrile-methyl acrylate copolymer (Barex® from BP Lima Chemicals, 1900 FORMANDA ROAD, LIMA, OH, USA) .. The atmosphere in the cylinder is evacuated and replaced with nitrogen gas. Both ends of the cylinder are sealed with aluminum foil. The foil is also coated with a layer of the same copolymer (Barex®) as heat-treated glass at the ends of the cylinder. The very specific modified acrylonitrile-methyl acrylate polymer used for this purpose has proven to be very expensive and difficult to handle. It has now surprisingly been found that a much cheaper material can be used to replace this copolymer and the invention is based on this finding. The invention Studies show that it is possible to use a polymeric material such as polyethylene terephthalate (PET), which has been subjected to surface modification by coating with inorganic oxides or arnorph carbon. The coating provides an approximately 5-10X improvement in oxygen impermeability and 2-4X improvement in water vapor permeability.
    Necessary investments in machines are reasonable and the capacity enables a short payback period as well as significant sustainable cost savings.
    The technology for surface modification has been developed sufficiently to realize the application. Coating of the inside or outside of 3D polymeric surfaces and 2D surfaces with inorganic oxides or amorphous carbon is already common to improve water vapor and oxygen barrier properties as well as electrical, optical, tribological and other properties.
    Current application areas include: - Beverages (including carbonated, alcoholic and non-alcoholic) - Food packaging - Medical plastics and packaging - Semiconductors - Lithium batteries There are different methods to achieve the desired plasma coating. Among these, we have found that methods and devices for plasma treatment described in e.g. U.S. Patents 6,015,595, 6,112,695, 6,180,191, 6,177,142, 6,180,185 and 6,539,890 are very useful. The contents of these patents are included in this application.
    Other examples of inorganic oxide or amorphous carbon coatings included in this application are as follows: Felts, John T., Plasma Deposited Silica Coatings for High Barrier Film and Rigid Containers, COEX 89 Conference, Princeton, New Jersey, 1989 Pasqui, A., Scateni, G., Beccaria, C., “Review of Processes for Clear Barrier Coating Today Available on the Market”, First Symposium of European Vacuum Coaters, Anzio, Italy, June 20-22, 1994 Johansson, Kenth S. , “Gas Barrier Properties of Plasma-deposited Coatings - Substrate Effects”, Polymer Surface Modification: Relevance to Adhesion, vol. 2 (Ed. K.L. Mittal), VSP, 2000 Naima Boutroy, Yann Pemel, J.M. Rius, Florence Auger, H.J .von Bardeleben, J .L. Cantin, F.
    Abel, Andreas Zeinert, C. Casiraghi, A.C. Ferrari and J. Robertson “Hydrogenated amorphous carbon film coating of PET bottles for gas diffusion ba1riers”, Diamond and related Matters, Volume 15, Issues 4-8, April-August 2006, Pages 921-927 By using, for example, the techniques described above : plastic and metal-based vacuum systems for RF (kHz and MHz); or microwave PECVD (Plasma Enhanced Chemical Vapor Deposition) or PVD (Physical Vapor Deposition) for coating the inside and / or outside of containers, the following advantages will be achieved compared to the state of the art: ° Use of cheaper plastic materials (cost reduction / simplification) ~ Good barrier properties inside cylinder with coating with Inorganic oxide or arnorft carbon.
    ° For end users verifiable product properties - passes all tests ~ Modular design - easily scalable ° Coats in and out at the same time The equipment based on the technology described above coats surfaces precisely regardless of the size and geometry of the container. It also handles cylindrical parts with open ends. The system currently allows a tolerance of + / -10% for a layer of 15 - 20 nm from the opening towards the center.
    Both the inner and outer surfaces could be covered with the help of the process. This is advantageous because it can provide a double barrier in a one-step or fl-step procedure. The thickness of the coating is controlled by the amount of energy and the speed of the machine. To guarantee a "pinhole" free coating, the surface to be coated must be free of particles.
    This is achieved by creating a linear gap between the injection molding machine and the coating machine and running these on line.
    PET is the recommended polymer because we have the most experience with it and because it has the right surface structure for nano-coating. The coating gives 5-10 X improvement of oxygen barrier while 2-4 X improvement of water vapor barrier.
    The compatibility against aggressive substances for the plasma-coated PET surface is excellent because the coating could be characterized as quartz, ie. cleaner than glass because it does not contain iron and sodium. This means that substances cannot migrate into the material or vice versa. The coating has been tested with typical food additives and certain solvents including acetone. The coating causes PET containers to remain unaffected if they are filled with acetone and stored.
    权利要求:
    Claims (1)
    [1]
    An extended shelf life nicotine dosing system containing a deionized amount of nicotine that can be selectively made available to a user, comprising: (a) a nicotine reservoir for holding and dispersing a measured amount of nicotine; (b) a sealed nicotine impermeable barrier formed as part of the nicotine reservoir, the barrier comprising at least one nicotine barrier layer consisting essentially of a polymer such as polyethylene terephthalate (PET), which polymer has been subjected to surface modification with inorganic oxides or arns; (c) wherein the barrier includes at least two adjacent surfaces heat sealed to form a continuous nicotine impermeable barrier so that the nicotine can be prevented from migrating outside the reservoir.
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    同族专利:
    公开号 | 公开日
    US9848641B2|2017-12-26|
    EP2448624A1|2012-05-09|
    US20120125353A1|2012-05-24|
    WO2011002375A1|2011-01-06|
    SE534196C2|2011-05-31|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    US4800903A|1985-05-24|1989-01-31|Ray Jon P|Nicotine dispenser with polymeric reservoir of nicotine|
    US4756964A|1986-09-29|1988-07-12|The Dow Chemical Company|Barrier films having an amorphous carbon coating and methods of making|
    US4809876A|1987-08-27|1989-03-07|Aluminum Company Of America|Container body having improved gas barrier properties|
    US5167242A|1990-06-08|1992-12-01|Kabi Pharmacia Aktiebolaq|Nicotine-impermeable container and method of fabricating the same|
    US5364666A|1993-09-23|1994-11-15|Becton, Dickinson And Company|Process for barrier coating of plastic objects|
    US5679412A|1993-10-28|1997-10-21|Manfred R. Kuehnle|Method and apparatus for producing gas impermeable, chemically inert container structures for food and volatile substances|
    US6112695A|1996-10-08|2000-09-05|Nano Scale Surface Systems, Inc.|Apparatus for plasma deposition of a thin film onto the interior surface of a container|
    US20030194517A1|2002-04-15|2003-10-16|Yu Shi|Coating compositions containing a silane additive and structures coated therewith|
    US6769436B2|2002-06-28|2004-08-03|Richard C. Horian|Volatile inhaler and method|
    EG23499A|2002-07-03|2006-01-17|Advanced Plastics Technologies|Dip, spray, and flow coating process for forming coated articles|
    DE10242086A1|2002-09-11|2004-04-15|Sig Technology Ltd.|Containers for packaging products, device for processing plastic and methods for producing containers|
    WO2004075933A2|2003-02-26|2004-09-10|Lavipharm S.A.|Devices for releasing volatile substances and methods of producing the devices|
    US20040182403A1|2003-02-28|2004-09-23|Sven-Borje Andersson|Container comprising nicotine and the use and manufacture thereof|
    DE10356925B4|2003-12-05|2006-05-11|Lts Lohmann Therapie-Systeme Ag|Inhaler for basic active pharmaceutical ingredients and process for its preparation|
    DE102004028369B4|2004-06-11|2007-05-31|Schott Ag|Method and device for treating substrates in a rotary machine|
    EP1898891A2|2005-05-13|2008-03-19|Alza Corporation|Multilayer drug delivery system with barrier against antagonist exposure|
    CH697933B1|2005-11-03|2009-03-31|Tetra Laval Holdings & Finance|Method and apparatus for coating plastic films with an oxide layer.|
    US20070172612A1|2006-01-23|2007-07-26|Plastipak Packaging, Inc.|Plastic container|US10279934B2|2013-03-15|2019-05-07|Juul Labs, Inc.|Fillable vaporizer cartridge and method of filling|
    US10244793B2|2005-07-19|2019-04-02|Juul Labs, Inc.|Devices for vaporization of a substance|
    US10039321B2|2013-11-12|2018-08-07|Vmr Products Llc|Vaporizer|
    US10076139B2|2013-12-23|2018-09-18|Juul Labs, Inc.|Vaporizer apparatus|
    US20160366947A1|2013-12-23|2016-12-22|James Monsees|Vaporizer apparatus|
    US10058129B2|2013-12-23|2018-08-28|Juul Labs, Inc.|Vaporization device systems and methods|
    HUE053511T2|2013-12-23|2021-07-28|Juul Labs Int Inc|Vaporization device systems|
    US10159282B2|2013-12-23|2018-12-25|Juul Labs, Inc.|Cartridge for use with a vaporizer device|
    US10512282B2|2014-12-05|2019-12-24|Juul Labs, Inc.|Calibrated dose control|
    DE202017007467U1|2016-02-11|2021-12-08|Juul Labs, Inc.|Fillable vaporizer cartridge|
    SG11201806801VA|2016-02-11|2018-09-27|Juul Labs Inc|Securely attaching cartridges for vaporizer devices|
    US10405582B2|2016-03-10|2019-09-10|Pax Labs, Inc.|Vaporization device with lip sensing|
    USD849996S1|2016-06-16|2019-05-28|Pax Labs, Inc.|Vaporizer cartridge|
    USD848057S1|2016-06-23|2019-05-07|Pax Labs, Inc.|Lid for a vaporizer|
    USD851830S1|2016-06-23|2019-06-18|Pax Labs, Inc.|Combined vaporizer tamp and pick tool|
    USD836541S1|2016-06-23|2018-12-25|Pax Labs, Inc.|Charging device|
    USD842536S1|2016-07-28|2019-03-05|Juul Labs, Inc.|Vaporizer cartridge|
    USD825102S1|2016-07-28|2018-08-07|Juul Labs, Inc.|Vaporizer device with cartridge|
    USD887632S1|2017-09-14|2020-06-16|Pax Labs, Inc.|Vaporizer cartridge|
    法律状态:
    2016-02-02| NUG| Patent has lapsed|
    优先权:
    申请号 | 申请日 | 专利标题
    SE0900880A|SE534196C2|2009-06-29|2009-06-29|Nicotine dosing system|SE0900880A| SE534196C2|2009-06-29|2009-06-29|Nicotine dosing system|
    US13/380,657| US9848641B2|2009-06-29|2010-06-18|Nicotine delivery system|
    PCT/SE2010/000171| WO2011002375A1|2009-06-29|2010-06-18|Nicotine delivery system|
    EP10794433A| EP2448624A1|2009-06-29|2010-06-18|Nicotine delivery system|
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